Introduction
Chronic pain makes life miserable, joyless, unbearable, we hope we may help by highlighting a path to wellness.
Find your joy!
The Causes
The prevalence of uric acid crystals in our tissues begets inflammation, often the inflammation concentrates in the joints (promoting arthritis).
Genetic factors can be involved in the development of gout, since low genetic expression of certain enzymes (in the purine salvage pathway) can lead to excessive amounts of uric acid, however, studies have shown that lifestyle determines the ramifications and particular manifestations of gout (6). Wherefore even a person genetically predisposed to contract the condition may avoid gout by following a thereto appropriate lifestyle.
Managing Gout
Resolving chronic gout requires long-standing reduction in serum uric acid.
So, how can we reduce uric acid levels?
An appropriate, where-to sufficient, lifestyle makeover is the optimal choice and can indeed lead to a significant reduction in uric acid load, whilst artificial pharmacological intervention with drugs such as NSAID, colchicine, corticosteroids, allopurinol are associated with unwanted effects; destroying mitochondrias; promoting decreased energy levels (12), hepatitis (20), allergic reactions, nephropathy (19) to name a few.
A Remedy Providing Protocol
How to use our instructions?
We are determined to help people derive lasting value from our recipes and protocols, we therefore recommend users bookmark this page, take-notes or print the instructions.
Lifestyle
Despite some disagreements, distinctions and nuances; acute flares of gout and chronic gouty arthritis arise from the same underlying cause: lifestyle choices promoting systemic acidosis.
Both conditions may however improve tremendously by adopting the following dietary regimen:
A low-protein, composed of colorful fruits and vegetables, plant centered diet.
The regimen prevents the formation of gout by alkalizing tissues, removing excess uric acid deposits, thereby reversing the degenerative gouty condition.
Advanced Regimen
Regenerating and Reversing Chronic Gout
A fruit based dietary regimen, combined with tissue specific herbs, followed for as long as necessary, designed to release chronic gout, will eventually ensure complete regeneration.
High water content fruits are an excellent antidote to hyperuricemia: lemons, grapes, cherries, apples, watermelons and oranges are extremely powerful as anti-uricemia agents; dissolving crystals, increasing elimination, reducing serum levels, by working as alkalizers; neutralizing tissue acidity; decreasing inflammation. Fruits are moreover full of phytonutrients protecting against oxidative stress and inflammation (9, 10, 11, 12), whilst inhibiting excessive xanthine oxidase (XO) and cyclooxygenase-1 (COX-1) enzymatic activities* (2, 3), and lowering uric acid levels.
* Enzymes that contributes to the gouty condition when hyperactive.
Including tissue specific herbs during the healing process will significantly increase the efficacy of the proposed regimen, since herbs are likewise, and often in greatly concentrated quantities, loaded with powerful phytochemicals aiding the body during the elimination of acids and the regeneration of tissues.
Short Term measures
When treating acute, painful, flares it is wise to avoid the use of aspirin since this can increase uric acid levels and counteract the regeneration process, instead herbal painkillers such as Willow bark, from which aspirin is actually derived, are tremendously applicable; providing efficient, immediate and temporary remedy, without side effects (see section below for details).
Pain Reducing Recipes
2 parts Willow bark (Salix spp.)
1 part Black cohosh (Cimicifuga racemosa)
1 part Nettles (Urtica dioica)
Consume 6 cups of this infusion daily, or in case of a tincture, 3 teaspoons 6 times a day mixed with juice or water, which will, hopefully, provide significant relief.
External Approaches
Useful tools to apply in addition to lifestyle change
Rosemary (1)
Semecarpus anacardium (ayurvedic: bhallakta) (3)
Orthosiphon stamineus (5)
Turmeric (8)
Boswellia Franckincense
Ginger
Stinging Nettle
Willow bark (pain killer for gouty attacks, alternative to NSAIDs)
Angelica archangelica / angelica sinensis
Fraxinus angustifolia (17)
Pistacia lentiscus (17)
Chrysanthemum indicum (18)
Cinnamomum cassia (18) (alternative to allopurinol)
Vitex negundo (21)
Ivy Gourd (21)
Powerful Herbs
If you are simply seeking; an effective, superior ready-made blend of highly beneficial herbs: we highly recommend the superior herbal formulas offered below.
The formulas, offered below, are crafted on the immortal principles of indian and western herbology, enhanced by modern technological advancements in extraction methods; providing optimal protection and synergistic action, by combining the two formulas below, benefits may be achieved even faster, due to the complementary nature of most herbs and herbal formulas.
Ayurvedic
Joint Health Capsules
A fun cheap and slightly time consuming option
If you enjoy the exotic fragrances of herbs and the process making your own admixtures: you may purchase the herbs separately and combine them at your leisure. (For an in-depth description of the process of self-assembling herbal preparations, see: Herbal Detoxification Tools)
Caution: if you are turned-off by unusual and sometimes bitter flavors; you may want to avoid this option.
We strongly recommend the following herbal suppliers; upholding a track record of excellence:
Mountain Rose Herbs are perhaps the foremost, broad spectrum, premium quality, herbal supplier in the world. 1stchineseherbs are market leading specialists in chinese herbology, herbal sources are rigorously examined and selected; ensuring purity and freshness, they furthermore offer a wide selection of herbs from across the world, subjected to the same standards of excellence, whilst Organic India offers a fine selection of outstanding traditional ayurvedic herbs, fair sourced and remarkably fair priced.
A Technical Perspective: Scientific References and Information
Deposits of uric acid crystals are associated with systemic acidosis (4), inflammation partially mediated by a harmful hyperactivity of inflammatory enzymes: xanthine oxidase (XO) and cyclooxygenase-1 (COX-1) (2, 3), and low activity of enzymes in the purine salvage pathway.
The enzyme XO catalyses the oxidation of hypoxanthine into xanthine, wherefrom uric acid is generated, therefore over-activity of XO causes the generation of detrimental concentrations of uric acid.
Foods high in purines, proteins and fats; such as animal flesh and dairy are significant upregulators of uric acid levels. Dairy contain high levels of XO, which is absorbed by the small intestine (14); exerting several malign roles; including contributing to the painful inflammatory response associated with gout. Furthermore, milk XO generates reactive oxidative species reducing cytochrome c, an important mitochondrial enzyme (13).
Fruits are loaded with benign phytochemicals exerting a powerful antioxidant capacity (9, 10, 11, 12), and modulating unbalanced enzyme activity; ameliorating excessive oxidative stress associated with XO enzyme performance (12). Fruit therefore inhibits excessive expression of the damage causing enzymes, whilst promoting an optimal cellular environment; reducing the proliferation of XO.
Try our programs at: BlissBlessHappiness.com
Questions and suggestion are welcomed...
References
1) Pharmacol Biochem Behav. 2011 Feb;97(4):683-9.
Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.
Martínez AL, González-Trujano ME, Chávez M, Pellicer F, Moreno J, López-Muñoz FJ.
2) Chem Biol Drug Des. 2011
Virtual and In vitro bioassay screening of phytochemical inhibitors from flavonoids and isoflavones against Xanthine oxidase and Cyclooxygenase-2 for gout treatment.
Li Y, Frenz CM, Li Z, Chen M, Wang Y, Li F, Luo C, Sun J, Bohlin L, Li Z, Yang H, Wang C.
3) J Ethnopharmacol. 2011 Feb 16;133(3):1117-20.
Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase.
Arimboor R, Rangan M, Aravind SG, Arumughan C.
4) Metabolism. 1972 May;21(5):433-45.
Comparison of urinary acidification and ammonium excretion in normal and gouty subjects.
Falls WF Jr.
5) J Ethnopharmacol. 2011 Jan 27;133(2):647-53.
Evaluation of the genotoxicity of Orthosiphon stamineus aqueous extract.
Muhammad H, Gomes-Carneiro MR, Poça KS, De-Oliveira AC, Afzan A, Sulaiman SA, Ismail Z, Paumgartten FJ.
6) Am J Med. 2012 Feb 22.
Nature Versus Nurture in Gout: A Twin Study.
Krishnan E, Lessov-Schlaggar CN, Krasnow RE, Swan GE.
7) Arch Intern Med. 2009 Mar 9;169(5):502-7.
Vitamin C intake and the risk of gout in men: a prospective study.
Choi HK, Gao X, Curhan G.
8) Int Immunopharmacol. 2010 May;10(5):605-10.
Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model.
Moon DO, Kim MO, Choi YH, Park YM, Kim GY.
9) Toxicology. 2000 Aug 7;148(2-3):187-97.
Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.
Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG.
10) British Journal of Nutrition (2010), 104, S67–S90
Berry flavonoids and phenolics: bioavailability and evidence of protective effects.
Daniele Del Rio, Gina Borges and Alan Crozier
11) Cellular Antioxidant Activity of Common Fruits
KELLY L. WOLFE,†,§ XINMEI KANG,†,§,# XIANGJIU HE,§ MEI DONG,§
QINGYUAN ZHANG,# AND RUI HAI LIU*,§
12) Carrasco-Pozo, C.; Gotteland, M.; Speisky, H.
Apple Peel Polyphenol Extract Protects against Indomethacin-Induced
Damage in Caco-2 Cells by Preventing Mitochondrial Complex I Inhibition . J. Agric. Food Chem. 2011, 59, 11501–1150
13) THE JOURNAL OF BIOLOGICAL CHEMISTRY
Vol. 243, No. 21, Issue of November 10, pp. 5753-5760, 1968
The Reduction of Cytochrome c by Milk Xanthine Oxidase*
JOE M. MCCORDJ AND IRWIN FRIDOVICH
14) Life Sci. 1976 Sep 15;19(6):887-92.
Xanthine oxidase activity in rat serum after administration of homogenized bovine cream preparation.
Clark AJ, Pratt DE.
15) The presence of ectopic xanthine oxidase in atherosclerotic plaques and myocardial tissues.
Ross DJ, Ptaszynski M, Oster KA.
Proc Soc Exp Biol Med. 1973 Nov;144(2):523-6.
16) Evaluation of serum cholesterol reduction and xanthine oxidase inhibition in the treatment of atherosclerosis.
Oster KA.
Recent Adv Stud Cardiac Struct Metab. 1973;3:73-80. .
17) J Med Food. 2010 Aug;13(4):896-904.
Kinetic study on the inhibition of xanthine oxidase by extracts from two selected Algerian plants traditionally used for the treatment of inflammatory diseases.
Berboucha M, et al.
18) J Ethnopharmacol. 2000 Nov;73(1-2):199-207.
Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout.
Kong LD, Cai Y, Huang WW, Cheng CH, Tan RX.
19) Hande, K.R., Noone, R.M., Stone, W.J., 1984. Severe allopurinol toxicity: description and guidelines for prevention inpatients with renal insufficiency. American Journal ofMedicine 76, 47–52
20) Urban, T., Maquarre, E., Housset, C., Chouaid, C., Devin, E.,
Lebeau, B., 1995. Allopurinol hypersensitivity. A possible
cause of hepatitis and mucocutaneous eruptions in a patient undergoing antitubercular treatment. Revue des Maladies Respiratoires 12, 314–316
21) J Ethnopharmacol. 2007 Feb 12;109(3):547-51.
Xanthine oxidase inhibitory activity of some Indian medical plants.
Umamaheswari M et al.
Chronic pain makes life miserable, joyless, unbearable, we hope we may help by highlighting a path to wellness.
Find your joy!
The Causes
The prevalence of uric acid crystals in our tissues begets inflammation, often the inflammation concentrates in the joints (promoting arthritis).
Genetic factors can be involved in the development of gout, since low genetic expression of certain enzymes (in the purine salvage pathway) can lead to excessive amounts of uric acid, however, studies have shown that lifestyle determines the ramifications and particular manifestations of gout (6). Wherefore even a person genetically predisposed to contract the condition may avoid gout by following a thereto appropriate lifestyle.
Managing Gout
Resolving chronic gout requires long-standing reduction in serum uric acid.
So, how can we reduce uric acid levels?
An appropriate, where-to sufficient, lifestyle makeover is the optimal choice and can indeed lead to a significant reduction in uric acid load, whilst artificial pharmacological intervention with drugs such as NSAID, colchicine, corticosteroids, allopurinol are associated with unwanted effects; destroying mitochondrias; promoting decreased energy levels (12), hepatitis (20), allergic reactions, nephropathy (19) to name a few.
-
By sowing the seeds of a new lifestyle and cultivating the holistic principles; the harvest will be of remedy!
Fortunately, moreover, the solution is harmless and sustainable; mostly devoid of side-effects.
A Remedy Providing Protocol
How to use our instructions?
We are determined to help people derive lasting value from our recipes and protocols, we therefore recommend users bookmark this page, take-notes or print the instructions.
Lifestyle
Despite some disagreements, distinctions and nuances; acute flares of gout and chronic gouty arthritis arise from the same underlying cause: lifestyle choices promoting systemic acidosis.
Both conditions may however improve tremendously by adopting the following dietary regimen:
A low-protein, composed of colorful fruits and vegetables, plant centered diet.
The regimen prevents the formation of gout by alkalizing tissues, removing excess uric acid deposits, thereby reversing the degenerative gouty condition.
Advanced Regimen
Regenerating and Reversing Chronic Gout
A fruit based dietary regimen, combined with tissue specific herbs, followed for as long as necessary, designed to release chronic gout, will eventually ensure complete regeneration.
High water content fruits are an excellent antidote to hyperuricemia: lemons, grapes, cherries, apples, watermelons and oranges are extremely powerful as anti-uricemia agents; dissolving crystals, increasing elimination, reducing serum levels, by working as alkalizers; neutralizing tissue acidity; decreasing inflammation. Fruits are moreover full of phytonutrients protecting against oxidative stress and inflammation (9, 10, 11, 12), whilst inhibiting excessive xanthine oxidase (XO) and cyclooxygenase-1 (COX-1) enzymatic activities* (2, 3), and lowering uric acid levels.
* Enzymes that contributes to the gouty condition when hyperactive.
Including tissue specific herbs during the healing process will significantly increase the efficacy of the proposed regimen, since herbs are likewise, and often in greatly concentrated quantities, loaded with powerful phytochemicals aiding the body during the elimination of acids and the regeneration of tissues.
Short Term measures
When treating acute, painful, flares it is wise to avoid the use of aspirin since this can increase uric acid levels and counteract the regeneration process, instead herbal painkillers such as Willow bark, from which aspirin is actually derived, are tremendously applicable; providing efficient, immediate and temporary remedy, without side effects (see section below for details).
Pain Reducing Recipes
- Prepare a powerful infusion (30 grams of dried herbs), or procure a strong herbal tincture (at least 3 parts herb to one part alcohol), containing:
2 parts Willow bark (Salix spp.)
1 part Black cohosh (Cimicifuga racemosa)
1 part Nettles (Urtica dioica)
Consume 6 cups of this infusion daily, or in case of a tincture, 3 teaspoons 6 times a day mixed with juice or water, which will, hopefully, provide significant relief.
External Approaches
- Apply castor oil packs on inflamed area to alleviate pain (to make castor oil packs see: castor oil).
- St. Johns Wort extracted in olive oil (red oil) applied on affected areas.
- A mixture of the following essential oils; peppermint, lavender, marjoram, rosemary, clove and franckincense, diluted with a carrier oil, may likewise help reduce symptoms.
- Aloe vera can be applied both internally and externally.
Useful tools to apply in addition to lifestyle change
-
Unrefined celtic sea salt baths can offer remedy: fill your bathtub with hot water and dissolve 2-3 kg or 4-6 pounds of salt in the tub. Put on some nice music and soak for as long as possible, several hours is preferable. Adding a natural source of so called "magnesium oil" will increase the efficaciousness of the treatment.
Rosemary (1)
Semecarpus anacardium (ayurvedic: bhallakta) (3)
Orthosiphon stamineus (5)
Turmeric (8)
Boswellia Franckincense
Ginger
Stinging Nettle
Willow bark (pain killer for gouty attacks, alternative to NSAIDs)
Angelica archangelica / angelica sinensis
Fraxinus angustifolia (17)
Pistacia lentiscus (17)
Chrysanthemum indicum (18)
Cinnamomum cassia (18) (alternative to allopurinol)
Vitex negundo (21)
Ivy Gourd (21)
Powerful Herbs
If you are simply seeking; an effective, superior ready-made blend of highly beneficial herbs: we highly recommend the superior herbal formulas offered below.
The formulas, offered below, are crafted on the immortal principles of indian and western herbology, enhanced by modern technological advancements in extraction methods; providing optimal protection and synergistic action, by combining the two formulas below, benefits may be achieved even faster, due to the complementary nature of most herbs and herbal formulas.
Ayurvedic
Joint Health Capsules
A fun cheap and slightly time consuming option
If you enjoy the exotic fragrances of herbs and the process making your own admixtures: you may purchase the herbs separately and combine them at your leisure. (For an in-depth description of the process of self-assembling herbal preparations, see: Herbal Detoxification Tools)
Caution: if you are turned-off by unusual and sometimes bitter flavors; you may want to avoid this option.
We strongly recommend the following herbal suppliers; upholding a track record of excellence:
Mountain Rose Herbs are perhaps the foremost, broad spectrum, premium quality, herbal supplier in the world. 1stchineseherbs are market leading specialists in chinese herbology, herbal sources are rigorously examined and selected; ensuring purity and freshness, they furthermore offer a wide selection of herbs from across the world, subjected to the same standards of excellence, whilst Organic India offers a fine selection of outstanding traditional ayurvedic herbs, fair sourced and remarkably fair priced.
A Technical Perspective: Scientific References and Information
Deposits of uric acid crystals are associated with systemic acidosis (4), inflammation partially mediated by a harmful hyperactivity of inflammatory enzymes: xanthine oxidase (XO) and cyclooxygenase-1 (COX-1) (2, 3), and low activity of enzymes in the purine salvage pathway.
The enzyme XO catalyses the oxidation of hypoxanthine into xanthine, wherefrom uric acid is generated, therefore over-activity of XO causes the generation of detrimental concentrations of uric acid.
Foods high in purines, proteins and fats; such as animal flesh and dairy are significant upregulators of uric acid levels. Dairy contain high levels of XO, which is absorbed by the small intestine (14); exerting several malign roles; including contributing to the painful inflammatory response associated with gout. Furthermore, milk XO generates reactive oxidative species reducing cytochrome c, an important mitochondrial enzyme (13).
Fruits are loaded with benign phytochemicals exerting a powerful antioxidant capacity (9, 10, 11, 12), and modulating unbalanced enzyme activity; ameliorating excessive oxidative stress associated with XO enzyme performance (12). Fruit therefore inhibits excessive expression of the damage causing enzymes, whilst promoting an optimal cellular environment; reducing the proliferation of XO.
Try our programs at: BlissBlessHappiness.com
Questions and suggestion are welcomed...
References
1) Pharmacol Biochem Behav. 2011 Feb;97(4):683-9.
Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.
Martínez AL, González-Trujano ME, Chávez M, Pellicer F, Moreno J, López-Muñoz FJ.
2) Chem Biol Drug Des. 2011
Virtual and In vitro bioassay screening of phytochemical inhibitors from flavonoids and isoflavones against Xanthine oxidase and Cyclooxygenase-2 for gout treatment.
Li Y, Frenz CM, Li Z, Chen M, Wang Y, Li F, Luo C, Sun J, Bohlin L, Li Z, Yang H, Wang C.
3) J Ethnopharmacol. 2011 Feb 16;133(3):1117-20.
Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase.
Arimboor R, Rangan M, Aravind SG, Arumughan C.
4) Metabolism. 1972 May;21(5):433-45.
Comparison of urinary acidification and ammonium excretion in normal and gouty subjects.
Falls WF Jr.
5) J Ethnopharmacol. 2011 Jan 27;133(2):647-53.
Evaluation of the genotoxicity of Orthosiphon stamineus aqueous extract.
Muhammad H, Gomes-Carneiro MR, Poça KS, De-Oliveira AC, Afzan A, Sulaiman SA, Ismail Z, Paumgartten FJ.
6) Am J Med. 2012 Feb 22.
Nature Versus Nurture in Gout: A Twin Study.
Krishnan E, Lessov-Schlaggar CN, Krasnow RE, Swan GE.
7) Arch Intern Med. 2009 Mar 9;169(5):502-7.
Vitamin C intake and the risk of gout in men: a prospective study.
Choi HK, Gao X, Curhan G.
8) Int Immunopharmacol. 2010 May;10(5):605-10.
Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model.
Moon DO, Kim MO, Choi YH, Park YM, Kim GY.
9) Toxicology. 2000 Aug 7;148(2-3):187-97.
Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.
Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG.
10) British Journal of Nutrition (2010), 104, S67–S90
Berry flavonoids and phenolics: bioavailability and evidence of protective effects.
Daniele Del Rio, Gina Borges and Alan Crozier
11) Cellular Antioxidant Activity of Common Fruits
KELLY L. WOLFE,†,§ XINMEI KANG,†,§,# XIANGJIU HE,§ MEI DONG,§
QINGYUAN ZHANG,# AND RUI HAI LIU*,§
12) Carrasco-Pozo, C.; Gotteland, M.; Speisky, H.
Apple Peel Polyphenol Extract Protects against Indomethacin-Induced
Damage in Caco-2 Cells by Preventing Mitochondrial Complex I Inhibition . J. Agric. Food Chem. 2011, 59, 11501–1150
13) THE JOURNAL OF BIOLOGICAL CHEMISTRY
Vol. 243, No. 21, Issue of November 10, pp. 5753-5760, 1968
The Reduction of Cytochrome c by Milk Xanthine Oxidase*
JOE M. MCCORDJ AND IRWIN FRIDOVICH
14) Life Sci. 1976 Sep 15;19(6):887-92.
Xanthine oxidase activity in rat serum after administration of homogenized bovine cream preparation.
Clark AJ, Pratt DE.
15) The presence of ectopic xanthine oxidase in atherosclerotic plaques and myocardial tissues.
Ross DJ, Ptaszynski M, Oster KA.
Proc Soc Exp Biol Med. 1973 Nov;144(2):523-6.
16) Evaluation of serum cholesterol reduction and xanthine oxidase inhibition in the treatment of atherosclerosis.
Oster KA.
Recent Adv Stud Cardiac Struct Metab. 1973;3:73-80. .
17) J Med Food. 2010 Aug;13(4):896-904.
Kinetic study on the inhibition of xanthine oxidase by extracts from two selected Algerian plants traditionally used for the treatment of inflammatory diseases.
Berboucha M, et al.
18) J Ethnopharmacol. 2000 Nov;73(1-2):199-207.
Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout.
Kong LD, Cai Y, Huang WW, Cheng CH, Tan RX.
19) Hande, K.R., Noone, R.M., Stone, W.J., 1984. Severe allopurinol toxicity: description and guidelines for prevention inpatients with renal insufficiency. American Journal ofMedicine 76, 47–52
20) Urban, T., Maquarre, E., Housset, C., Chouaid, C., Devin, E.,
Lebeau, B., 1995. Allopurinol hypersensitivity. A possible
cause of hepatitis and mucocutaneous eruptions in a patient undergoing antitubercular treatment. Revue des Maladies Respiratoires 12, 314–316
21) J Ethnopharmacol. 2007 Feb 12;109(3):547-51.
Xanthine oxidase inhibitory activity of some Indian medical plants.
Umamaheswari M et al.
Gout and Arthritis
Find Remedy!
Find Remedy!
